5-MAPB is not itself listed in the SATA, but because it is structurally linked to MDMA, it can be considered illegal in Canada, although this has not been tested in court.  As of July 2021, 5-MAPB is not listed in the list of prohibited substances.  It is therefore still a legal substance. The best research chemical store to order 5-MAPB is the linked Amsterdam Smartshop. This is considered the largest online drug store in Europe. There you can seriously and discreetly buy 5-MAPB and order many other drugs. For very large quantities at low prices, you can also go to the Darknet. We will present both possibilities in detail below. Please do not act illegally and respect the laws of your country of residence! 5-MAPB is an amino-methylated derivative of 5-APB, an amphetamine-type synthetic drug.
The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research purposes. You should not add often, once can always be correct at a moderate dose, but each additional addition increases the side effects and hangover the next day but drastically. We combined this 5-APB benzofide with hydrochloride, making it perfect for a variety of research purposes. Its molecular formula is C11H13NO HCl, and it also goes under the name of 5-(2-amino-propyl) benzofurane. New psychoactive substances (NPS) are becoming increasingly common worldwide, although their pharmacological properties are largely unknown; Those with stimulant properties have addictive potential due to interactions with the dopamine transporter (DAT) that their users may not recognize. We investigated the binding of 1-(1-benzofuran-5-yl)-N-methylpropane-2-amine (5-MAPB) to the striatal DAT of rats by quantitative autoradiography with [125I]RTI-121 and the effects of 5-MAPB on dopamine discharge electrically evoked by rapid cyclic voltammetry in rat brain sections. 5-MAPB replaced [125I]RTI-121 as a function of concentration, with significant effects at 10 and 30 μM. Voltammetry data suggest that 5-MAPB reduces dopamine reuptake rates; Although the maximum flow of dopamine was not increased, the area under the curve was increased. 5-MAPB can also cause reverse dopamine transport, which is consistent with the properties of stimulants more similar to amphetamine than cocaine.
Molecular modelling and docking studies compared the DAT binding site in the complex with 5-MAPB with dopamine, amphetamine, 5-APB, MDMA, cocaine and RTI-121. This structural comparison shows a binding mode for 5-MAMB found at the primary binding site (S1), which is central for transmembrane domains 1, 3, 6 and 8 and overlaps the binding modes of dopamine, cocaine and its analogues. Atomistic molecular dynamics simulations also show that DATs in the complex with 5-MAPB may have conformational transitions that spontaneously isomerize the transporter into an inward-directed state, similar to dopamine-bound DAT. These new findings, which result from the combination of computational methods of biophysics with neurobiological methods, provide a structural context for NPS in DAT and link it to its functional properties in DAT as a molecular target of stimulants. Molecular weight: HCl: 225.7 g/mol, Freebase: 189.25 g/mol The optical component appears to be more pronounced in this substance than in MDMA. Some users report that the effect of 5-MAPB is also a little clearer than with comparable substances, but this is very subjective. The dosage of this empathogen is sometimes very different, which can be due either to the fact that the quality of the substance varies greatly or that it acts very differently in different people, or because HCl as well as the Freebase form are in circulation. 100mg of MDMA corresponds to the potency of about 30-50mg of 5-MAPB. The notable agonism of 5-MAPB at the serotonin-2b receptor (5-HT2b) (which has been associated with cardiovalvular heart disease) suggests that it would be cardiotoxic with long-term use, as seen in other 5-HT2B agonists such as fenfluramine and MDMA. Instead of buying it in the Legal Highs Shop, you can also order 5-MAPB in the Darknet. This would be particularly useful if one wanted to order larger quantities of 1-(benzofuran-5-yl)-N-methylpropane-2-amine. Home » Buy and Order » 5-MAPB: Buy, Effect, Experiments, Dosage It should be noted, however, that the psychedelic effects caused by 5-APB are not as strong as similar effects caused by compounds with similar structures.
The Freebase must be dosed much lower than the HCl, because it is more powerful!! The difference between 5-MAPB Freebase and HCl is similar to MDMA, Freebase is 16% more powerful. In other words, there are extremely few studies on the mechanism of action of 5-MAPB so far. It is likely that the substance, similar to MDMA, acts primarily as a selective inhibitor of serotonin reuptake (SSRI) and serotonin release (RAS). Presumably, it also acts, but less strongly, as a reabsorbent inhibitor of dopamine and norepinephrine. We also published an article on closely related 5-BPAs and 6-BPAs. The differences in action between 5-MAPB and 6-APB are described in the “Effect of 5-MAPB” section! 5-MAPB was initially banned in the UK in June 2013 as part of a temporary class of medicines.  On March 5, 2014, the UK Home Office announced that on June 10, 2014, 5-MAPB would become a Class B drug alongside any other entactogenic benzofurane and many structurally related drugs.  Compared to 6-APB, it has an equally strong empathogenic and euphoric effect, but 5-MAPB is much more sedative and less stimulating. 5-MAPB often comes in the form of succinate and hydrochloride salt. Hydrochloride salt is 36% stronger by mass, so doses should be adjusted accordingly. [Citation needed] As it is an amphetamine, 5-MAPB falls under the German NPS law.